Custom ambient mass spectrometry imaging instrumentation
We construct and develop custom instrumentation to map metabolite distributions in tissue and engineer strategies to expand the range of metabolites detected.
Non-targeted spatial metabolomics
Data analysis and metabolite annotation for non-targeted molecular histology of 2D tissue sections.
Mass spectrometry imaging of low abundance metabolites.
We use reactive chemistries and targeted ionization enhancements to uncover the spatial distribution of metabolites in tissue with low physiological abundance but high biological significance.
Direct MS differentiation of metabolite isomers
Unique ionization chemistries are explored to yield structurally diagnostic product ions for isomerically resolved MS/MS fragmentation.